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Maladar is an antimalarial combination medication that contains the active ingredients sulfadoxine and pyrimethamine. The combination of these two drugs is used for the treatment and prevention of certain types of malaria.

It particularly those caused by the Plasmodium falciparum parasite which is resistant to other antimalarial drugs. The combination is often referred to as SP (sulfadoxine-pyrimethamine).

Sulfadoxine: It belongs to the class of medicines known as sulfonamides. It inhibits the synthesis of dihydrofolic acid in the parasite, which is essential for its survival and multiplication.

Pyrimethamine: This drug inhibits dihydrofolate reductase, another enzyme necessary for the synthesis of folic acid in the parasite.



Manufactured By

Efroze Chemical Industries

Product Form


Generic category 


Active Ingredient

sulfadoxine 500mg/5ml





  • It's essential to follow the dosage regimen prescribed by a medical professional.
  • In some regions, this combination is used as Intermittent Preventive Treatment (IPT) in pregnant women and infants.
  • Pregnant or breastfeeding women should consult a doctor before using this medication.
  • Individuals with a known allergy to sulfonamides or pyrimethamine should avoid this medication.
  • Regular blood tests may be required to monitor for potential blood disorders, especially during prolonged therapy.
  • It's essential to ensure that the medication is appropriate for the specific strain of malaria being treated, given the potential for drug resistance.



Like all medications, sulfadoxine-pyrimethamine can have side effects. Common side effects can include:

  • Nausea
  • Vomiting
  • Dizziness
  • Itchy skin or rash



What is sulfadoxine-pyrimethamine (SP)?

Sulfadoxine-pyrimethamine is a combination medication used to treat and prevent certain types of malaria, primarily those caused by Plasmodium falciparum parasites.

How does SP work against malaria?

SP contains two active ingredients, sulfadoxine and pyrimethamine, which work together to disrupt the growth and multiplication of the malaria parasite. Sulfadoxine inhibits the synthesis of dihydrofolic acid, while pyrimethamine inhibits dihydrofolate reductase, both of which are essential for the parasite's survival.

What is SP used for?

SP is used both for the treatment of malaria and as a preventive measure. It is often used in pregnant women and infants in certain regions as Intermittent Preventive Treatment (IPT).


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